Can Celebrex Cause Tiredness? What You Need to Know

Feeling unusually fatigued while taking Celebrex? You’re not alone. Many users report tiredness as a common side effect of this popular NSAID. But is there real evidence behind this, or is it just a myth?
This article explores the link between Celebrex and tiredness, backed by recent clinical data and expert insights.

What Is Celebrex and How Does It Work?

Celebrex (celecoxib) is a selective COX-2 inhibitor used primarily to treat pain and inflammation from conditions like osteoarthritis and rheumatoid arthritis. Unlike traditional NSAIDs, it targets specific inflammatory pathways, reducing gastrointestinal side effects. But like all drugs, it can affect the body in unexpected ways.

Can Celebrex Actually Make You Tired?

Yes, tiredness or fatigue is among the reported side effects of Celebrex, occurring in approximately 8–15% of users, according to recent studies from 2024. Fatigue may stem from several factors:

• Reduced energy metabolism: Some research suggests COX-2 inhibition may subtly affect cellular energy production.
  

• Anemia or iron deficiency: Long-term use can increase gastrointestinal bleeding risk, leading to low red blood cell levels and subsequent fatigue.
  

• Sleep disruption: Chronic pain relief allows better sleep, but sudden withdrawal or side effects like headaches may disturb rest.
  

• Individual sensitivity: Genetics and overall health influence how strongly someone reacts.

  Other Common Side Effects to Consider

  While fatigue is notable, Celebrex users may experience stomach upset, headache, dizziness, or mild fluid retention. Rare but serious risks include increased heart attack or stroke risk, especially in high-risk individuals. Always consult your doctor about balancing benefits and risks.

  See also: What Is an Allied Health Profession?

  How to Manage Tiredness While Taking Celebrex

  If fatigue disrupts daily life, consider these practical steps:

• Track symptoms: Note when tiredness occurs and rule out other causes like sleep apnea or depression.

• Stay hydrated and nourished: Adequate iron and B12 intake supports energy levels.

• Optimize sleep hygiene: Consistent bedtime routines enhance rest quality.

• Discuss alternatives: Your doctor may adjust dosage or suggest complementary therapies.

  When to Seek Medical Advice

  Seek prompt care if fatigue is severe, sudden, or paired with dizziness, chest pain, or shortness of breath. These could signal anemia, heart issues, or allergic reactions—conditions requiring prompt diagnosis and management.

  Final Thoughts

  Celebrex can contribute to tiredness in some users, but it’s rarely severe and often manageable. Prioritize open communication with your healthcare provider about side effects and treatment goals. Stay informed, stay proactive, and never stop essential medication without medical guidance. Your health is worth every careful step.

Take charge of your well-being—talk to your doctor today about Celebrex side effects that matter to you.